Neuromedin U Receptor (NMUR)
Neuromedin U Receptor
Neuromedin U Receptor belongs to the G protein-coupled receptors family and is classified as Class A. Neuromedin U Receptor can bind the neuropeptide hormones neuromedin U and neuromedin S. Neuromedin U Receptor includes NMUR1 and NMUR2. NMUR1 is mainly expressed in peripheral tissues such as the gastrointestinal tract, while NmU-R2 is mainly expressed in the central nervous system. Neuromedin U Receptor can mediate intracellular signal transduction such as Ca2+ and regulate the physiological functions of multiple systems such as the gastrointestinal tract, cardiovascular system, and neuroendocrine system, for example, affecting smooth muscle contraction, blood pressure, feeding, energy balance, and stress responses. Neuromedin U Receptor is closely related to the occurrence and development of diseases such as cancer, pain, metabolic diseases, and gastrointestinal diseases, and is a highly potential target for disease treatment[1].
Neuromedin U Receptor (NMUR) Isoform Specific Products
All Product Categories
-
Neuromedin U Receptor (NMUR) Related Products (13)
Related Products (13)
-
Neuromedin U Receptor (NMUR) Isoform Comparison
- 1
-
Neuromedin U, rat TFA
0 ImagesCat. No.: HY-P1238APurity: 99.90%Synonyms: Neuromedin U (rat) TFA; Rat neuromedin U-23 TFANeuromedin U, rat TFA is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.
-
CPN-351 TFA
0 ImagesCat. No.: HY-P10473APurity: 99.60%
-
R-PSOP
0 ImagesR-PSOP is highly potent and selective nonpeptidic NMUR2 antagonist. R-PSOP binds to NMUR2 with the Kis of 52 and 32 nM for the human and rat NMUR2, respectively. R-PSOP shows moderate CNS penetration. R-PSOP can be used for the research of the eating disorders, obesity, pain, and stress-related disorders.
-
CPN-267 TFA
0 ImagesCat. No.: HY-P3134APurity: 99.64%CPN-267 (compound 7b) TFA is a selective neuromedin U receptor 1 (NMUR1) agonist with the EC50 of 0.25 nM. CPN-267 TFA suppresses body weight gain in mice and can be used for study of obesity.
-
3'-Methoxyflavonol
0 Images3'-Methoxyflavonol is a selective agonist of neuromedin U 2 receptor (NMU2R).
-
CPN-267
0 ImagesCat. No.: HY-P3134CAS No.: 2241236-26-8CPN-267 (compound 7b) is a selective neuromedin U receptor 1 (NMUR1) agonist with the EC50 of 0.25 nM. CPN-267 suppresses body weight gain in mice and can be used for study of obesity.
-
CPN-116
0 ImagesCat. No.: HY-P3135CAS No.: 1620490-70-1CPN-116 is a NMUR2 agonist. CPN-116 can be used in the research of obesity.
-
Neuromedin S (human)
0 ImagesCat. No.: HY-P5084CAS No.: 1138204-27-9Neuromedin S (human) is a neuropeptide that contains 33 amino acids. Neuromedin S (human)has been identified in the brain as an endogenous ligand for the orphan G-protein coupled receptor (GPCR) FM-4/TGR-1 and acts on the neuromedin U (NMU) receptor 2 (NMUR2) in the regulation of body weight homeostasis.
-
Neuromedin U, rat
0 ImagesCat. No.: HY-P1238CAS No.: 117505-80-3Synonyms: Neuromedin U (rat); Rat neuromedin U-23Neuromedin U, rat is a 23-amino acid brain-gut peptide. Neuromedin U (NMU), through its cognate receptor NMUR2 in the central nervous system, regulates several important physiological functions, including energy balance, stress response, and nociception.
-
3'-Methoxyflavonol (Standard)
0 ImagesCat. No.: HY-N6629RCAS No.: 76666-32-5Prednisolone acetate (Standard) is the analytical standard of Prednisolone acetate. This product is intended for research and analytical applications. Prednisolone acetate (Prednisolone 21-acetate) is an adrenocortical hormone active molecule with various pharmacological effects such as anti-inflammatory, anti-allergic, and immune suppression.
-
NY0116
0 ImagesCat. No.: HY-124681CAS No.: 1003000-59-6NY0116 is a neuromedin U receptor 2 (NMUR2) agonist with EC50 values of 27.76 μM for hNMUR1 and 13.61 μM for hNMUR2. NY0116 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells.
- 1
